Bioactive glass nanotube scaffold with well-ordered mesoporous structure for improved bioactivity and controlled drug delivery
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2019年第9期
论文作者：Jian Xiao Yizao Wan Zhiwei Yang Yuan Huang Fanglian Yao Honglin Luo
文章页码：1959 - 1965
摘 要：In this study, a novel mesoporous bioactive glass nanotube（MBGN） scaffold has been fabricated via template-assisted sol-gel method using bacterial cellulose（BC） as template and nonionic block copolymer（P123） as pore-directing agent. The scaffold was characterized by scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, Fourier-transform infrared（FTIR） spectroscopy, and N2 adsorption-desorption analysis. Furthermore, simvastatin was used to evaluate the loading efficiency and release kinetics of the scaffold. The obtained scaffold displays nanofiber-like morphology, ordered mesopores on the tube walls, and interconnected three-dimensional（3 D） network structure that completely replicates the BC template. In addition, it shows dual pore sizes（16.2 and 3.3 nm）, large specific surface area(537.2 m2 g-1) and pore volume(1.429 cm3 g-1). More importantly, the scaffold possesses excellent apatite-forming ability and sustainable drug release as compared to the counterpart scaffold without mesopores. This unique scaffold can be considered a promising candidate for drug delivery and bone tissue regeneration.
Jian Xiao1，Yizao Wan1,2，Zhiwei Yang2，Yuan Huang1，Fanglian Yao3，Honglin Luo1,2
1. School of Materials Science and Engineering, Tianjin University2. Institute of Advanced Materials, School of Materials Science and Engineering, East China Jiaotong University3. Key Laboratory of Systems Bioengineering of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University
摘 要：In this study, a novel mesoporous bioactive glass nanotube（MBGN） scaffold has been fabricated via template-assisted sol-gel method using bacterial cellulose（BC） as template and nonionic block copolymer（P123） as pore-directing agent. The scaffold was characterized by scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, Fourier-transform infrared（FTIR） spectroscopy, and N2 adsorption-desorption analysis. Furthermore, simvastatin was used to evaluate the loading efficiency and release kinetics of the scaffold. The obtained scaffold displays nanofiber-like morphology, ordered mesopores on the tube walls, and interconnected three-dimensional（3 D） network structure that completely replicates the BC template. In addition, it shows dual pore sizes（16.2 and 3.3 nm）, large specific surface area(537.2 m2 g-1) and pore volume(1.429 cm3 g-1). More importantly, the scaffold possesses excellent apatite-forming ability and sustainable drug release as compared to the counterpart scaffold without mesopores. This unique scaffold can be considered a promising candidate for drug delivery and bone tissue regeneration.
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