Synthesis and Characterization of a Novel Silver-Substituted Calcium Phosphate Cement
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2014年第7期
论文作者：Tao Yu Chengying Gao Jiandong Ye Ming Zhang
文章页码：686 - 691
摘 要：Antibacterial materials play an important role in clinical application,and silver has been known to exhibit strong cytotoxicity towards a broad range of micro-organisms.In this work,the amorphous calcium phosphate with silver substitution（Ag-ACP） was synthesized by chemical precipitation method,and the valence of silver in ACP was adjusted by temperature.The processed Ag-ACP was combined with slightly acidic compounds to form new calcium phosphate cement（CPC）.Our results indicate that the valence of silver in CPC was adjusted successfully by chemical precipitation method and heat treatment.X-ray diffraction（XRD） and X-ray photoelectron spectroscopy（XPS） results demonstrated that silver ion in CPC-1 and CPC-2 existed in Ag3PO4;after heat treatment of 460 ℃,silver became more stable in CPC-3 and CPC-4.Silver in CPC-1 and CPC-2exhibited better releasing property.After heat treatment at 460 ℃,the amount of silver ion released from CPC decreased significantly.Besides,the antibacterial ability of Ag-CPC was adjusted by changing the valence of silver in Ag-CPC.Depending on the low valence of silver and good silver release,CPC-1 and CPC-2exhibited better antibacterial activity.We believe that this study will motivate the development and applications of antibacterial CPC in bone tissue regeneration.
Tao Yu1,2，Chengying Gao1，Jiandong Ye1，Ming Zhang2
1. Key Laboratory of Specially Functional Materials of Ministry of Education and School of Materials Science and Engineering,South China University of Technology2. Interdisciplinary Division of Biomedical Engineering,The Hong Kong Polytechnic University
摘 要：Antibacterial materials play an important role in clinical application,and silver has been known to exhibit strong cytotoxicity towards a broad range of micro-organisms.In this work,the amorphous calcium phosphate with silver substitution（Ag-ACP） was synthesized by chemical precipitation method,and the valence of silver in ACP was adjusted by temperature.The processed Ag-ACP was combined with slightly acidic compounds to form new calcium phosphate cement（CPC）.Our results indicate that the valence of silver in CPC was adjusted successfully by chemical precipitation method and heat treatment.X-ray diffraction（XRD） and X-ray photoelectron spectroscopy（XPS） results demonstrated that silver ion in CPC-1 and CPC-2 existed in Ag3PO4;after heat treatment of 460 ℃,silver became more stable in CPC-3 and CPC-4.Silver in CPC-1 and CPC-2exhibited better releasing property.After heat treatment at 460 ℃,the amount of silver ion released from CPC decreased significantly.Besides,the antibacterial ability of Ag-CPC was adjusted by changing the valence of silver in Ag-CPC.Depending on the low valence of silver and good silver release,CPC-1 and CPC-2exhibited better antibacterial activity.We believe that this study will motivate the development and applications of antibacterial CPC in bone tissue regeneration.
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