Preparation and Characterization of Superparamagnetic Fe3O4/CNTs Nanocomposites Dual-drug Carrier
来源期刊：Journal Of Wuhan University Of Technology Materials Science Edition2017年第1期
论文作者：张小娟 WANG Hehe ZHU Xingqun ZHANG Zhiying HU Xiaohong JIANG Wei
文章页码：42 - 46
摘 要：Fe3O4/carbon nanotubes（Fe3O4/CNTs） nanocomposites were prepared by polylol hightemperature decomposition of the precursor ferric chloride and CNTs in liquid triethylene glycol.After surface modification with hexanediamine,folate was covalently linked to the amine group of magnetic Fe3O4/CNTs nanocomposites.The products were characterized by Fourier-transform infrared spectroscopy,transmission electron microscopy,and vibrating sample magnetometry.Then Fe3O4/CNTs were used as a dual-drug carrier to co-delivery of the hydrophilic drug epirubicin hydrochloride and hydrophobic drug paclitaxel.The results indicated that the Fe3O4/CNTs had a favorable release property for epirubicin and paclitaxel,and thus had potential application in tumor-targeted combination chemotherapy.
张小娟1，WANG Hehe1，ZHU Xingqun1，ZHANG Zhiying1，HU Xiaohong1，JIANG Wei2
1. School of Material Engineering, Jinling Institute of Technology2. National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology
摘 要：Fe3O4/carbon nanotubes（Fe3O4/CNTs） nanocomposites were prepared by polylol hightemperature decomposition of the precursor ferric chloride and CNTs in liquid triethylene glycol.After surface modification with hexanediamine,folate was covalently linked to the amine group of magnetic Fe3O4/CNTs nanocomposites.The products were characterized by Fourier-transform infrared spectroscopy,transmission electron microscopy,and vibrating sample magnetometry.Then Fe3O4/CNTs were used as a dual-drug carrier to co-delivery of the hydrophilic drug epirubicin hydrochloride and hydrophobic drug paclitaxel.The results indicated that the Fe3O4/CNTs had a favorable release property for epirubicin and paclitaxel,and thus had potential application in tumor-targeted combination chemotherapy.
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