Effect of Cerium on Cardiac Muscle of Rat and Guinea Pig
来源期刊：JOURNAL OF RARE EARTHS2000年第1期
论文作者：XIANG Hui YANG Yan-sheng SHEN Zhi-guo LEI Heng-yi
Key words：rare earths; cerium; action potential; cardiac muscle; rat; guinea pig;
Abstract: The effect of Ce3+ on cardiac muscle of rat and guinea pig was studied. In vitro, 0.05 mmol.L-1 solution of Ce3+ inhibited the contraction of guinea pig atria. The change of action potential duration(APD) of guinea pig papillary muscle exposed to 0.4 mmol·L-1 Ce3+ was significant, and those exposed to 0.1 and 0.2 mmol·L-1 Ce3+ were not significant. In vivo, compared with the control group, the APD for rat cardiac muscle after long-term feed on Ce3+ was significantly delayed in high dose, and that was not significantly delayed in low dose. The results suggest that Ce3+ with long-term high dose intake might affect the influx of Ca2+, Na+ and outflow of K+ for rat cardiac muscle.
XIANG Hui1，YANG Yan-sheng2，SHEN Zhi-guo2，LEI Heng-yi2
(1.School of Life Sciences, Zhongshan University, Guangzhou 510275, China;
2.School of Chemistry and Chemical Engineering)
Abstract:The effect of Ce3+ on cardiac muscle of rat and guinea pig was studied. In vitro, 0.05 mmol.L-1 solution of Ce3+ inhibited the contraction of guinea pig atria. The change of action potential duration(APD) of guinea pig papillary muscle exposed to 0.4 mmol·L-1 Ce3+ was significant, and those exposed to 0.1 and 0.2 mmol·L-1 Ce3+ were not significant. In vivo, compared with the control group, the APD for rat cardiac muscle after long-term feed on Ce3+ was significantly delayed in high dose, and that was not significantly delayed in low dose. The results suggest that Ce3+ with long-term high dose intake might affect the influx of Ca2+, Na+ and outflow of K+ for rat cardiac muscle.
Key words:rare earths; cerium; action potential; cardiac muscle; rat; guinea pig;
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