Microstructure, Mechanical Properties, Corrosion Behavior and Biocompatibility of As-Extruded Biodegradable Mg–3Sn–1Zn–0.5Mn Alloy
来源期刊：JOURNAL OF MATERIALS SCIENCE TECHNOLOG2016年第9期
论文作者：Lida Hou Zhen Li Hong Zhao Yu Pan Sergey Pavlinich Xiwei Liu Xinlin Li Yufeng Zheng Li Li
文章页码：874 - 882
摘 要：The microstructure evolution and mechanical properties of biodegradable Mg–3Sn–1Zn–0.5Mn alloys were investigated by the optical microscopy, X-ray diffractometer and a universal material testing machine.The corrosion and degradation behaviors were studied by potentiodynamic polarization method and immersion test in a simulated body fluid（SBF）. It was found that the as-extruded Mg–3Sn–1Zn–0.5Mn alloy has the fine equiaxed grains which underwent complete dynamic recrystallization during the hot extrusion process, with the second phase particles of Mg2Sn precipitated on the grain boundaries and inside the grains. The tensile strength and elongation of as-extruded Mg–3Sn–1Zn–0.5Mn alloys were 244 ± 3.7 MPa and 19.3% ± 1.7%, respectively. The potentiodynamic polarization curves in SBF solution indicated the better corrosion resistance of the as-extruded Mg–3Sn–1Zn–0.5Mn alloy in the SBF solution. Immersion test in the SBF solution for 720 h revealed that the corrosion rate of as-extruded Mg–3Sn–1Zn–0.5Mn alloy was nearly 4 ± 0.33 mm/year. The hemolysis rate of as-extruded Mg–3Sn–1Zn–0.5Mn alloy was lower than the safe value of 5% according to ISO 10993-4. As-extruded Mg–3Sn–1Zn–0.5Mn alloy showed good biocompatibility after being implanted into the dorsal muscle and the femoral shaft of the rabbit, and no abnormalities were found after short-term implantation. It was revealed that the as-extruded Mg–3Sn–1Zn–0.5Mn alloy is a promising material for biodegradable implants,which possesses an interesting combination of preferred mechanical properties, better corrosion resistance and biocompatibility.
Lida Hou1，Zhen Li1,2，Hong Zhao3，Yu Pan1，Sergey Pavlinich1，Xiwei Liu1，Xinlin Li1，Yufeng Zheng1,4，Li Li1,2
1. Center for Biomedical Materials and Engineering, Harbin Engineering University2. Institute of Materials Processing and Intelligent Manufacturing, Harbin Engineering University3. Hospital of Heilongjiang Province4. Department of Materials Science and Engineering, College of Engineering, Peking University
摘 要：The microstructure evolution and mechanical properties of biodegradable Mg–3Sn–1Zn–0.5Mn alloys were investigated by the optical microscopy, X-ray diffractometer and a universal material testing machine.The corrosion and degradation behaviors were studied by potentiodynamic polarization method and immersion test in a simulated body fluid（SBF）. It was found that the as-extruded Mg–3Sn–1Zn–0.5Mn alloy has the fine equiaxed grains which underwent complete dynamic recrystallization during the hot extrusion process, with the second phase particles of Mg2Sn precipitated on the grain boundaries and inside the grains. The tensile strength and elongation of as-extruded Mg–3Sn–1Zn–0.5Mn alloys were 244 ± 3.7 MPa and 19.3% ± 1.7%, respectively. The potentiodynamic polarization curves in SBF solution indicated the better corrosion resistance of the as-extruded Mg–3Sn–1Zn–0.5Mn alloy in the SBF solution. Immersion test in the SBF solution for 720 h revealed that the corrosion rate of as-extruded Mg–3Sn–1Zn–0.5Mn alloy was nearly 4 ± 0.33 mm/year. The hemolysis rate of as-extruded Mg–3Sn–1Zn–0.5Mn alloy was lower than the safe value of 5% according to ISO 10993-4. As-extruded Mg–3Sn–1Zn–0.5Mn alloy showed good biocompatibility after being implanted into the dorsal muscle and the femoral shaft of the rabbit, and no abnormalities were found after short-term implantation. It was revealed that the as-extruded Mg–3Sn–1Zn–0.5Mn alloy is a promising material for biodegradable implants,which possesses an interesting combination of preferred mechanical properties, better corrosion resistance and biocompatibility.
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