Eu(Ⅲ) Indirect Probe to Investigate Interaction of DOPA (3,4, Di-Hydroxyphenylalanine) and Dopamine (3,4-Dihydroxy Phenyl Ethyl Amine) Using Electrochemical Methods
来源期刊：JOURNAL OF RARE EARTHS2006年第6期
论文作者：G. Ramchandraiha Prashant N Bhatt Trupti V Pathak Jignasu P Mehta
Key words：electrochemistry of Eu (Ⅲ); chrono techniques; electrochemistry of Eu(Ⅲ)-neurotransmitters; solution study; rare earths;
Abstract: Eu(Ⅲ) can be utilized as an indirect electrochemical probe to investigate the interaction of bio-molecules such as DOPA and Dopamine with Ca(Ⅱ) in vitro. The interaction of DOPA and Dopamine with Eu(Ⅲ)-Eu(Ⅱ) redox pair was investigated by electrochemical techniques. Both the neurotransmitters are structurally related and undergo interaction with Eu(Ⅲ). Eu(Ⅲ) coordinates with DOPA and Dopamine through five-member chelate rings via carboxylic oxygen and amino nitrogen. The electrode kinetic parameters viz, transfer coefficient (αna), diffusion coefficient (D), forward heterogeneous rate constant (k0fh) were evaluated for Eu(Ⅲ)-DOPA/Eu(Ⅲ)-Dopamine. The results obtained were used to investigate the nature of interaction of Eu(Ⅲ) with multi-donor biomolecules. The possible mechanism was also proposed.
G. Ramchandraiha1，Prashant N Bhatt2，Trupti V Pathak2，Jignasu P Mehta2
(1.Central Salt and Marine Chemical Research Institute, Waghavadi Road, Bhavnagar-364002, India;
2.Department of Chemistry, Bhavnagar University, Bhavnagar-364002, India)
Abstract:Eu(Ⅲ) can be utilized as an indirect electrochemical probe to investigate the interaction of bio-molecules such as DOPA and Dopamine with Ca(Ⅱ) in vitro. The interaction of DOPA and Dopamine with Eu(Ⅲ)-Eu(Ⅱ) redox pair was investigated by electrochemical techniques. Both the neurotransmitters are structurally related and undergo interaction with Eu(Ⅲ). Eu(Ⅲ) coordinates with DOPA and Dopamine through five-member chelate rings via carboxylic oxygen and amino nitrogen. The electrode kinetic parameters viz, transfer coefficient (αna), diffusion coefficient (D), forward heterogeneous rate constant (k0fh) were evaluated for Eu(Ⅲ)-DOPA/Eu(Ⅲ)-Dopamine. The results obtained were used to investigate the nature of interaction of Eu(Ⅲ) with multi-donor biomolecules. The possible mechanism was also proposed.
Key words:electrochemistry of Eu (Ⅲ); chrono techniques; electrochemistry of Eu(Ⅲ)-neurotransmitters; solution study; rare earths;
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